Ceftibuten dihydrate

CAS No. 118081-34-8

Ceftibuten dihydrate( Sch-39720 dihydrate )

Catalog No. M22032 CAS No. 118081-34-8

Ceftibuten dihydrate is the dihydrate form of ceftibuten, and is a third-generation cephalosporin with antibacterial activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Ceftibuten dihydrate
  • Note
    Research use only, not for human use.
  • Brief Description
    Ceftibuten dihydrate is the dihydrate form of ceftibuten, and is a third-generation cephalosporin with antibacterial activity.
  • Description
    Ceftibuten dihydrate is the dihydrate form of ceftibuten, and is a third-generation cephalosporin with antibacterial activity.(In Vitro):Ceftibuten (Sch-39720) is highly active against Haemophilus influenza, Escherichia coli, Klebsiella sp., and Proteus sp. and moderately active against Serratia sp. and Streptococcus pyogenes. Ceftibuten is relatively inactive against enterococci and staphylococci and is only weakly active against Pseudomonas aeruginosa and obligate anaerobes. It is also stable in the presence of most β-lactamase-producing organisms except βBacteroides fragilis. Ceftibuten is very active against strains of the family Enterobacteriaceae (mean MIC for 90% of strains=0.25 μg/ml) but less active against Campylobacterjejuni (mean MIC for 90% of strains=16.0 μg/ml).(In Vivo):Ceftibuten, a biologically stableβ-lactam antibiotic, has been shown to be transported by the small peptide transport system, to have relatively high affinity for the carrier and to show clear stereoselective and proton-gradient dependent transport characteristics in rat intestinal brush-border membrane vesicles.
  • In Vitro
    Ceftibuten (Sch-39720) is highly active against Haemophilus influenza, Escherichia coli, Klebsiella sp., and Proteus sp. and moderately active against Serratia sp. and Streptococcus pyogenes. Ceftibuten is relatively inactive against enterococci and staphylococci and is only weakly active against Pseudomonas aeruginosa and obligate anaerobes. It is also stable in the presence of most β-lactamase-producing organisms except βBacteroides fragilis. Ceftibuten is very active against strains of the family Enterobacteriaceae (mean MIC for 90% of strains=0.25 μg/ml) but less active against Campylobacterjejuni (mean MIC for 90% of strains=16.0 μg/ml).
  • In Vivo
    Ceftibuten, a biologically stableβ-lactam antibiotic, has been shown to be transported by the small peptide transport system, to have relatively high affinity for the carrier and to show clear stereoselective and proton-gradient dependent transport characteristics in rat intestinal brush-border membrane vesicles.
  • Synonyms
    Sch-39720 dihydrate
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Bacterial|Antibiotic
  • Research Area
    Urinary system
  • Indication
    Pyelonephritis

Chemical Information

  • CAS Number
    118081-34-8
  • Formula Weight
    446.46
  • Molecular Formula
    C15H18N4O8S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:95 mg/mL (212.78 mM; Need ultrasonic)
  • SMILES
    C1C=C(N2C(S1)C(C2=O)NC(=O)C(=CCC(=O)O)C3=CSC(=N3)N)C(=O)O.O.O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. JONES, RONALD N. Ceftibuten: a review of antimicrobial activity, spectrum and other microbiologic features.[J]. Pediatric Infectious Disease Journal, 1995, 14(14):S77-83.
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